Circadian clock could play key role in the fight against liver cancer

Circadian clock could play key role in the fight against liver cancer

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Nov 8 2018The body’s internal clock could play a critical role in the fight against certain types of liver cancer, according to a preclinical study by scientists from The University of Texas Health Science Center at Houston (UTHealth). The results were published recently in the journal Nature Communications.The body’s clock, called the circadian clock, is an intrinsic, 24-hour timekeeping system that operates in all cells of the body and regulates sleep, metabolism and other vital body functions.”We were able to inhibit the growth of liver cancer in a mouse model by manipulating the circadian clock at the cellular level,” said Kristin Eckel-Mahan, Ph.D., the study’s senior author and an assistant professor with the Center for Metabolic and Degenerative Diseases at McGovern Medical School at UTHealth.Related StoriesLiver fat biomarker levels linked with metabolic health benefits of exercise, study findsSugary drinks linked to cancer finds studyStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryEckel-Mahan said researchers confirmed their findings in human tissue samples.In 2015, 32,908 new cases of liver cancer were reported, and 25,760 people died of liver cancer in the United States, reported the Centers for Disease Control and Prevention.Eckel-Mahan’s team identified a malfunctioning protein that was inhibiting the expression of a key circadian transcription factor and blocking the ability of a tumor suppressor to perform its normal 24-hour cellular functions. When investigators forced the tumor cells to re-express the deficient circadian protein, the tumor cells died.Fifty percent of liver tumors express this malfunctioning protein, which induces circadian dysfunction in those cells, said Eckel-Mahan, whose laboratory is in the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth.The study focused on hepatocellular carcinoma (HCC), the leading liver malignancy found in humans and the second-leading cause of all malignancy-related cancer deaths. Hepatocellular carcinoma is on the rise and has been linked to obesity-associated fatty liver disease.”These results suggest that targeting the circadian clock in HCC may be a promising treatment for the growth and progression of HCC tumors,” the authors wrote.She said the next steps are to determine how to prevent disruption of the clock in the first place and to study whether pharmacological approaches known to improve clock function can also prevent the growth of these liver tumors.Source: https://www.uth.edu/media/story.htm?id=84421455-3237-4e69-907f-ea147ee242e6last_img read more

New initiative may benefit entrepreneurs working to transform patient care

New initiative may benefit entrepreneurs working to transform patient care

first_img Source:https://www.uml.edu/ Reviewed by James Ives, M.Psych. (Editor)Nov 9 2018Entrepreneurs working to improve the lives and promote the independence of patients may soon benefit from an initiative run by the Massachusetts Medical Device Development Center (M2D2).A joint partnership between UMass Lowell and UMass Medical School in Worcester, M2D2 is a business incubator that helps medical-device and biotech startups bridge the gap between idea and market.Supported by a $7.9 million grant from the National Institutes of Health (NIH), M2D2 will establish a new center to assist inventors pioneering promising new point-of-care devices and technologies for patients with heart, lung, blood and sleep disorders. Innovations aim to help patients with these health concerns better manage their well-being wherever they are, seeking to reduce in-patient hospital stays and improve quality of life.Taken together, heart, lung and blood diseases account for 41 percent of deaths in the United States and lead to more than $400 billion in health-care expenses and lost income to patients and caregivers, according to the National Heart, Lung and Blood Institute’s Fact Book for Fiscal Year 2012. Innovations supported by the center will be devices and technologies well on their way to going to market.The new initiative, called the Center for Advancing Point-of-Care Technologies (CAPCaT), will be driven by the talent and aspirations of participating entrepreneurs, along with the expertise of scientists, business developers, legal experts and resources available at UMass Lowell and UMass Medical School in collaboration with industry partners. The center is one of four being launched with support from the NIH to help revolutionize patient care and will provide entrepreneurs with seed funding and access to an array of stakeholders including patients, caregivers and clinicians.”Our partnership with UMass Medical School and the NIH’s National Heart, Lung, and Blood Institute is innovative and exciting. We are energized by the opportunity to continually reimagine and grow the medical and biotech industries to help improve people’s lives,” said Steven Tello, a member of M2D2’s executive board and UMass Lowell’s vice provost of innovation and workforce development. “The incubator will be a home base for startups advancing new point-of-care medical technologies and devices that will transform health care.”Examples of innovations to be developed at the center include portable devices and sensors that measure the amount of medication in a patient’s blood, products that use smart devices to record heart or respiratory rates and technologies that alert patients to health changes such as worsening asthma. The center also seeks to support technologies that promote holistic methods to managing diseases, including devices that measure stress levels or promote mindfulness.Related StoriesSleep quality and fatigue among women with premature ovarian insufficiencyAn active brain and body associated with reduced risk of dementiaResearch sheds light on sun-induced DNA damage and repair”The new center will address the urgent need to bring to market medical technologies and devices that can be used to provide fast, accurate information to patients anywhere they are, empowering them to better monitor their conditions and get on with their daily lives,” said M2D2 Founder and Director Stephen McCarthy, chairman of UMass Lowell’s Biomedical Engineering Department, who will co-direct CAPCaT.Entrepreneurs working on innovations that are close to being tested in clinical settings are invited to apply to join the new center. Applicants may be physicians, doctorate-level faculty from any U.S. college or university, or an officer of a small business based within the United States. Successful applicants will receive seed funding and the support of M2D2’s medical, business and legal experts; professionals in the private sector; and staff from the National Heart, Lung, and Blood Institute and National Center for Complementary and Integrative Health. Entrepreneurs, engineers, inventors and scientists interested in more information should email M2D2@uml.edu.”The new business accelerator will facilitate collaborations between faculty researchers and private industry to commercialize new technologies more quickly and efficiently. The goal of these new tools is to help clinicians and health-care systems deliver higher quality care at a lower cost,” said M2D2 Co-Director Nate Hafer, Ph.D., who is also director of operations at the UMass Center for Clinical and Translational Science at UMass Medical School.The new center plans to open inside M2D2 at UMass Lowell and UMass Medical School by the end of the year. Members of the CAPCaT team include Associate Prof. Ainat Koren of UMass Lowell’s Solomont School of Nursing and UMass Lowell Professor Emeritus of Biomedical and Nutritional Sciences Eugene Rogers in UMass Lowell’s Zuckerberg College of Health Sciences.M2D2’s support of medical device startups in Massachusetts has contributed $42 million in direct economic impact with a total positive effect of $75 million and 370 jobs, according to a 2015 report by the UMass Donahue Institute. Targeted expansion of these efforts through CAPCaT and M2D2 is expected to increase this impact, according to Tello.”The center will bring the tremendous talent at UMass Lowell and UMass Medical School together to provide a strong infrastructure for technology development, both inside and outside our institutions, to help transform the regional economy and enhance care and outcomes for patients with heart, lung and sleep disorders,” said David McManus, M.D., ScM, cardiologist and co-director of the Center for Data Driven Discovery at UMass Medical School who is co-leading the project with McCarthy.last_img read more

Meningococcal bacteria with antibiotic resistance are at risk of increasing worldwide

Meningococcal bacteria with antibiotic resistance are at risk of increasing worldwide

first_imgDec 19 2018In a new report published in Expert Review of Vaccines, the Global Meningococcal Initiative (GMI) – a leading group of scientists, doctors and public health officials – warns that the incidence of meningococcal meningitis strains with resistance to traditional antibiotics is at risk of increasing worldwide.Over the past 50 years, vaccines that prevent some types of meningococcal disease (which can cause meningitis) and antibiotics that prevent and treat the disease, have significantly reduced cases and deaths in many countries.Research shows that meningococcal bacteria are able to acquire genes from other strains and that genes that give the bacteria reduced susceptibility or complete resistance to life-saving antibiotics can be passed from one type of bacteria to another.In the war between bacteria and antibiotics, this means ever higher dosages of antibiotics are needed and eventually they may stop working altogether. Without alternatives, the bacteria will eventually win, and there are worrying signs this is at risk of happening for certain types of meningitis in the future.Scientists were concerned to discover strains of meningococcal bacteria that have acquired genes from closely related gonorrhea, a leading cause of sexually transmitted disease. This is particularly concerning as gonorrhea that is resistant to most antibiotic treatments (super-resistant gonorrhea) is a major world-wide problem.Professor Ray Borrow, GMI Chair said: Vinny Smith, GMI Steering Group Member and Chief Executive at Meningitis Research Foundation said: Meningitis and septicemia are deadly diseases that can have a devastating impact on individuals and their families. It’s far better to prevent the diseases through vaccination than to rely on treatment with antibiotics, especially given the rising threat of antibiotic resistance.  Meningitis spreads around the world and we need a coordinated effort to defeat it. This year the World Health Organization launched an expert taskforce to develop a global roadmap to defeat meningitis by 2030, and MRF is delighted to be taking part.” Sam Nye, Executive Director at the Confederation of Meningitis Organisations said: Source:https://www.meningitis.org/news/meningitis-becoming-more-resistant-to-antibiotics Today, we have critical tools to help fight meningitis – antibiotics and vaccines. With increasing antibiotic resistance, we will lose one of these tools, leaving infants, children and adults at higher risk of the devastating consequences of meningitis, such as long-term disability and even death.We work with meningitis advocacy groups all over the world to promote the importance of vaccines; vaccines not only have the capability to save lives today, they can also help to reduce the spread of antibiotic resistance, saving millions of lives in future years.” Antibiotic resistance is a major threat to human health. It’s clear that global surveillance of the strains causing meningococcal disease, as well as surveillance of antibiotic resistance, is vitally important. This would ensure that any emergent strains that pose a significant threat are identified early so that routine and reactive vaccination programmes with suitable vaccines can be quickly introduced.”last_img read more

JUUL raises nicotine levels in its ecigarettes

JUUL raises nicotine levels in its ecigarettes

first_imgExperts in the report said that the e-cigarettes have undone the decades of public health messages and campaigns that have tried to keep children and teenagers away from nicotine. The company initially used 1 to 2 percent nicotine refills that has been ramped up to 5 percent refills. This has spurred other vaping companies to raise their nicotine levels as well and now almost all refills are at 5 to 7 percent. “When Juul came out with very high-nicotine electronic cigarettes, it triggered a nicotine arms race amongst competitive companies seeking to emulate the success of Juul,” Jackler said.Related StoriesNicotine could affect human embryonic development at the single-cell levelStudy explores adolescent vaping and its association with delinquencyGiving credible information about tobacco and nicotine productsA 5 percent pod can deliver nicotine amounts equivalent to a pack of cigarettes write the authors of the study. Jackler explained that these high amounts of nicotine may “be a benefit to addicted adult smokers,” who were trying to quit smoking, “but it also makes it potently addictive to nicotine-naive teenagers.”Researchers report that Juul had developed the “nicotine salt” which masks the bitter taste of nicotine and allows consumers to take in more amounts. This rise in nicotine levels in their products has not only made the e-cigarettes more addictive but also more affordable as well. The refills are mostly priced on the pod and not the refill. United Kingdom and Israel have restricted their sales to 1.7 percent refills only while Americans are getting the higher end refills.There is a steady rise in vaping among teenagers in the US and health advocates are calling upon restricting laws and regulations from the US Food and Drug Administration. The FDA said in its 2017 statement that it is, “committed to encouraging innovations that have the potential to make a notable public health difference and inform policies and efforts that will best protect kids and help smokers quit cigarettes.” “This action will afford the agency time to explore clear and meaningful measures to make tobacco products less toxic, appealing and addictive,” the agency said.Juul spokeswoman Victoria Davis in a statement said, “As part of our commitment to prevent underage use, we are taking swift and decisive action against counterfeit and infringing products.” Source:https://tobaccocontrol.bmj.com/content/early/2019/01/31/tobaccocontrol-2018-054796 Image Credit: Oneinchpunch / Shutterstockcenter_img By Dr. Ananya Mandal, MDFeb 7 2019Popular e-cigarette manufacturer Juul is one of the fastest growing vaping companies around. It has been targeting youngsters and adolescents with their flavoured e-cigarettes. The company has recently come under scrutiny for steadily raising the nicotine content of its e-cigarettes.A report stating the rise of nicotine in Juul’s e-cigarettes and its impact on other vaping companies was published in the latest issue of the BMJ journal Tobacco Control in a study titled, “Nicotine arms race: JUUL and the high-nicotine product market.” It comes from a team of Stanford researchers led by Dr. Robert Jackler, founder of Stanford Research into the Impact of Tobacco Advertising and co-authored by Divya Ramamurthi.last_img read more

YouTube labels statesponsored news as rules tighten

YouTube labels statesponsored news as rules tighten

YouTube on Friday began labeling news broadcasts that get government money as it vowed to be stricter about content at the globally popular online video-sharing service. YouTube said it is labeling news videos coming from state-funded organizations as part of an effort to improve transparency Explore further YouTube toughens rules regarding which videos get ads Citation: YouTube labels state-sponsored news as rules tighten (2018, February 3) retrieved 18 July 2019 from https://phys.org/news/2018-02-youtube-state-sponsored-news-tighten.html © 2018 AFP A feature being rolled out in the US displays notices below videos uploaded by news broadcasters which receive government or public money, according to a blog post by YouTube News senior product manager Geoff Samek.”Our goal is to equip users with additional information to help them better understand the sources of news content that they choose to watch on YouTube,” Samek said”News is an important vertical for us and we want to be sure to get it right.”The move is likely to affect videos from services such as Russia-backed RT, which critics call a propaganda outlet for Moscow, but others as well.The blog post included a screen shot with a disclaimer about the US government-funded Radio Free Asia. The flagging may also apply to state-chartered news organizations such as the BBC and AFP, and US-based public broadcasters.Notices displayed with state-sponsored news broadcasts will include links to Wikipedia online encyclopedia so viewers can find out more about agencies behind the reports, according to Samek.The feature is nascent and will be refined based on feedback from users.YouTube made a series of changes last year intended to “better surface authoritative news,” according to Samek.YouTube priorities for this year include tightening and better enforcing rules at the service, according to chief executive Susan Wojcicki.”The same creativity and unpredictability that makes YouTube so rewarding can also lead to unfortunate events where we need to take a clear, informed, and principled stance,” Wojcicki said in an online post.”We realize we have a serious social responsibility to get these emerging policy issues right.”Solutions being worked on include enhanced software smarts and more human review of videos uploaded to YouTube, according to Wojcicki. The number of workers at YouTube and Google focused on content that might violate policies was to increase to more than 10,000.”We’re also currently developing policies that would lead to consequences if a creator does something egregious that causes significant harm to our community as a whole,” Wojcicki said.YouTube last month announced ramped-up rules regarding when it will run ads with videos as it scrambled to quell concerns by brands about being paired with troublesome content.YouTube late last year pulled 150,000 videos of children after lewd comments about them were posted by viewers. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

German court paves way for diesel driving bans Update

German court paves way for diesel driving bans Update

Judges to rule on diesel bans in choking German cities A top German court on Tuesday ruled that cities can impose diesel driving bans to combat air pollution, in a landmark decision that could shake up the auto industry and upend transport policies. An environmental activist demonstrated last week in front of the Federal Administrative Court in Leipzig, eastern Germany, where the court is considering the legality of banning driving diesel cars when pollution reaches high levels. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Harmful fine particles and nitrogen oxides (NOx)from diesel engines has made it difficult for many cities to meet pollution targets. Judges at the Federal Administrative Court in Leipzig found that local authorities have the right to ban older, dirty diesels from their city centres—plunging millions of drivers into uncertainty.The court did not impose such bans itself, leaving that up to city and municipal authorities. The judges did however urge them to “exercise proportionality” in enforcing the bans, and said any curbs should be introduced gradually.The case centred around the smog-clogged cities of Stuttgart and Duesseldorf, but could have nationwide repercussions.The outcome marks a major victory for the environmentalist group Deutsche Umwelthilfe (DUH), which sued Stuttgart and Duesseldorf to force them to take action against the toxic nitrogen oxides and fine particles emitted by older diesel engines.Lower-level judges had already backed their demand for driving bans but the states of Baden-Wuerttemberg and North Rhine-Westphalia appealed the rulings, saying such curbs should be decided at the federal level.But judges at the nation’s top administrative court again sided with the environmental campaigners.”It’s a great day for clean air in Germany,” said DUH chief Juergen Resch.Greenpeace also welcomed the verdict. “Every city can now defend its citizens’ right to clean air,” the environmental group’s spokesman Niklas Schinerl said.The ruling will come as blow to the government and the nation’s mighty auto industry who strongly oppose driving bans, fearing outrage from diesel owners whose lives stand to be disrupted and whose vehicles could lose their resale value.In a nod to those concerns, presiding judge Andreas Korbmacher said “certain losses will have to be accepted”.He also urged city and municipal authorities to avoid “a patchwork” of local measures.Critics had earlier argued that the bans would be complicated to enforce and cause confusion among drivers. Explore further It estimates that some 10 million vehicles will be affected across the country.Ahead of the closely-watched court decision, the German transport ministry had signalled it was already preparing for possible bans, with plans for slimmed-down version of diesel curbs appearing in the media over the weekend.According to the proposals, the ministry could later this year update traffic regulations to include the option of city-ordered diesel bans on certain routes.Concerns over the harmful effects of diesel have soared since Volkswagen admitted in 2015 to installing cheating devices in millions of cars that allowed them to secretly spew far more nitrogen oxide than legally allowed.The poisonous gases have been linked to respiratory illnesses and heart problems, and are responsible for thousands of premature deaths each year.Other carmakers have also come under suspicion for curbing or shutting off emissions controls, shattering diesel’s “clean” reputation.Mounting pressureThe industry has responded to “dieselgate” by offering software upgrades and trade-ins for newer, cleaner models but it has resisted calls for costly hardware fixes.DUH chief Resch however said Tuesday’s ruling could finally put real pressure on automakers to retrofit older cars with properly functioning emissions controls.”I now expect the auto industry to deliver,” he said.Chancellor Angela Merkel’s government meanwhile has offered a billion-euro fund, partly paid for by industry, to improve public transport or upgrade fleets to electric buses.Such measures are intended at least as much for eyes in Brussels—where Germany and a slew of other EU member states risk legal action after sailing past a deadline to reduce air pollution—as for those in town halls.Some 70 German cities including Munich, Stuttgart and Cologne recorded average nitrogen dioxide levels above EU thresholds in 2017, according to the Federal Environment Agency. © 2018 AFP Citation: German court paves way for diesel driving bans (Update) (2018, February 27) retrieved 18 July 2019 from https://phys.org/news/2018-02-car-mad-germany-anxious-court-diesel.html 10 million carsAnalysts at EY consultancy said drivers of all but the latest diesel models that adhere to the Euro 6 standards “can no longer be certain of being allowed to drive at any time, 365 days a week”. read more

Amazon to quiet Alexas cackling

Amazon to quiet Alexas cackling

Explore further Users of smart speakers with Alexa assistant software have comically expressed their fears in recent weeks on Twitter, even posting video snippets of speakers infused with the software laughing menacingly for no apparent reason.”If Alexa is laughing at you to your face, just imagine what it says about you behind your back,” read a quip posted at Twitter by @mattblaze.Darker posts wondered playfully whether fears about artificial intelligence turning on humans were coming real.”Every time Alexa laughs, an angel dies,” entrepreneur and innovator Elon Musk joked in a Twitter exchange on the development.Tesla co-founder Musk is among high profile figures who have called for vigilance to ensure artificial intelligence doesn’t turn on humans.Amazon told AFP it looked into what was going on and found that sometimes Alexa mistakenly registers the phrase “Alexa laugh” and obeys.”We are changing that phrase to be ‘Alexa, can you laugh?’ which is less likely to have false positives,” an Amazon spokesperson told AFP.And, Alexa is being modified to say “Sure, I can laugh,” before cackling.Streaming television titan Netflix took the opportunity to spotlight a Black Mirror dystopian series known for twisted, unanticipated consequences of new technologies.”Just brainstorming some @blackmirror titles while Alexa laughs maniacally in the distance,” read an @netflix tweet.The tweet included a picture of a multi-story, modern book shop overlaid with “The Bookstore That Enslaved Humanity.”Amazon began as an online book seller.One video of a cackling Alexa posted at Twitter on February 23 had logged more than a million views.”I unplugged Alexa and she’s still laughing,” one Twitter user quipped.Launched in 2014 by Amazon, the Alexa digital assistant has spread from the company’s Echo voice-commanded speakers to millions of devices, even cars.Alexa competes in the digital assistant market with offerings from tech titans including Apple, Google, and Microsoft. © 2018 AFP Google Assistant adds more languages in global push Amazon has promised to keep virtual assistant Alexa from spontaneously cackling, giving people eerie feelings about what the artificial intelligence might be plotting Citation: Amazon to quiet Alexa’s cackling (2018, March 8) retrieved 18 July 2019 from https://phys.org/news/2018-03-amazon-quiet-alexa-cackling.html Amazon on Wednesday promised to keep virtual assistant Alexa from spontaneously cackling, giving people eerie feelings about what the artificial intelligence might be plotting. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Detecting deepfake videos in the blink of an eye

Detecting deepfake videos in the blink of an eye

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. A new form of misinformation is poised to spread through online communities as the 2018 midterm election campaigns heat up. Called “deepfakes” after the pseudonymous online account that popularized the technique – which may have chosen its name because the process uses a technical method called “deep learning” – these fake videos look very realistic. How deepfake videos are made. When a deepfake algorithm is trained on face images of a person, it’s dependent on the photos that are available on the internet that can be used as training data. Even for people who are photographed often, few images are available online showing their eyes closed. Not only are photos like that rare – because people’s eyes are open most of the time – but photographers don’t usually publish images where the main subjects’ eyes are shut.Without training images of people blinking, deepfake algorithms are less likely to create faces that blink normally. When we calculate the overall rate of blinking, and compares that with the natural range, we found that characters in deepfake videos blink a lot less frequent in comparison with real people. Our research uses machine learning to examine eye opening and closing in videos. This gives us an inspiration to detect deepfake videos. Subsequently, we develop a method to detect when the person in the video blinks. To be more specific, it scans each frame of a video in question, detects the faces in it and then locates the eyes automatically. It then utilizes another deep neural network to determine if the detected eye is open or close, using the eye’ appearance, geometric features and movement.We know that our work is taking advantage of a flaw in the sort of data available to train deepfake algorithms. To avoid falling prey to a similar flaw, we have trained our system on a large library of images of both open and closed eyes. This method seems to work well, and as a result, we’ve achieved an over 95 percent detection rate.This isn’t the final word on detecting deepfakes, of course. The technology is improving rapidly, and the competition between generating and detecting fake videos is analogous to a chess game. In particular, blinking can be added to deepfake videos by including face images with closed eyes or using video sequences for training. People who want to confuse the public will get better at making false videos – and we and others in the technology community will need to continue to find ways to detect them. Before they can work properly, deep neural networks need a lot of source information, such as photos of the persons being the source or target of impersonation. The more images used to train a deepfake algorithm, the more realistic the digital impersonation will be.Detecting blinkingThere are still flaws in this new type of algorithm. One of them has to do with how the simulated faces blink – or don’t. Healthy adult humans blink somewhere between every 2 and 10 seconds, and a single blink takes between one-tenth and four-tenths of a second. That’s what would be normal to see in a video of a person talking. But it’s not what happens in many deepfake videos. Provided by The Conversation Citation: Detecting ‘deepfake’ videos in the blink of an eye (2018, August 29) retrieved 18 July 2019 from https://phys.org/news/2018-08-deepfake-videos-eye.html This article was originally published on The Conversation. Read the original article. I never said that! High-tech deception of ‘deepfake’ videoscenter_img So far, people have used deepfake videos in pornography and satire to make it appear that famous people are doing things they wouldn’t normally. But it’s almost certain deepfakes will appear during the campaign season, purporting to depict candidates saying things or going places the real candidate wouldn’t.Because these techniques are so new, people are having trouble telling the difference between real videos and the deepfake videos. My work, with my colleague Ming-Ching Chang and our Ph.D. student Yuezun Li, has found a way to reliably tell real videos from deepfake videos. It’s not a permanent solution, because technology will improve. But it’s a start, and offers hope that computers will be able to help people tell truth from fiction.What’s a ‘deepfake,’ anyway?Making a deepfake video is a lot like translating between languages. Services like Google Translate use machine learning – computer analysis of tens of thousands of texts in multiple languages – to detect word-use patterns that they use to create the translation. A real person blinks while talking. It’s actually very hard to find photos of people with their eyes closed. Credit: Bulin/Shutterstock.com A simulated face doesn’t blink the way a real person does. It’s Barack Obama – or is it? Deepfake algorithms work the same way: They use a type of machine learning system called a deep neural network to examine the facial movements of one person. Then they synthesize images of another person’s face making analogous movements. Doing so effectively creates a video of the target person appearing to do or say the things the source person did. Explore furtherlast_img read more

Tonga Whole country cut off from Facebook YouTube

Tonga Whole country cut off from Facebook YouTube

first_img Explore further Tonga has been plunged into virtual cyber darkness after an undersea cable was cut Tonga has been plunged into virtual cyber darkness after an undersea cable broke, cutting off the Pacific island kingdom from almost all cell phone and Internet services. Citation: Tonga: Whole country cut off from Facebook, YouTube (2019, January 23) retrieved 17 July 2019 from https://phys.org/news/2019-01-tonga-country-facebook-youtube.html Tonga declares Zika epidemic after five confirmed casescenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. While life without the Internet may be considered a paradise for many, Tonga relies heavily on links with the outside world for daily supplies and vital tourist earnings, and faced “an absolute disaster” as officials struggled to fix the problem.”We are all heavily tied to the Internet for doing business and for the government,” Mary Fonua, editor of the online news service Matangi Tonga, told AFP on Wednesday.”There’s no Facebook, which is how the Tongan diaspora communicate with each other, businesses can’t get orders out, airlines can’t take bookings for passengers or freight.” While the authorities look into the cause and struggle to find a solution, they have turned to a small, locally operated satellite connection as back-up.In the meantime non-essential social media sites like Facebook have been blocked to preserve much-needed bandwidth.The restricted access also meant serious problems getting money transfers through for families who rely on income from relatives working overseas. “It’s an absolute disaster for Tonga, a national crisis,” Fonua said.Tonga Cable, which administers the 827-kilometre (514-mile)cable between Tonga and Fiji, said Internet traffic had to be prioritised until repairs were completed, and in the meantime social media websites may be blocked while the country of 110,000 relies on makeshift connectivity.”Eighty percent of our international traffic is from social media,” Tonga Cable director Paula Piukala told Radio New Zealand.”We may block Facebook, YouTube and stuff like that in the meantime so that we can maximise the small bandwidth that we have from satellite on what is important to the country.”At the Bank of South Pacific Tonga, acting operations manager Salesi Fineangano said telex transfers could be completed via satellite connection to the bank headquarters in Papua New Guinea, “but we need the regular internet connection for Moneygram, internet banking and emails”.Officials said it could take up to two weeks to fix the cable. © 2019 AFPlast_img read more

Huawei says it plans to invest 31 billion in Italy

Huawei says it plans to invest 31 billion in Italy

first_img Citation: Huawei says it plans to invest $3.1 billion in Italy (2019, July 15) retrieved 17 July 2019 from https://phys.org/news/2019-07-huawei-invest-billion-italy.html Huawei—a leader in next-generation 5G wireless technology—is subject to US sanctions over concerns about its ties to the government in Beijing and Washington has urged allies to shun the firm.Announcing the investment plan Huawei’s managing director for Italy Thomas Miao said trade tensions between the US and China were not having an impact on Huawei’s business in Italy for now.”The (Italian) government has an open and transparent policy that will not be affected by the problems between the United States and China,” he told a press conference in Milan.”Over the next three years, we will invest $1.9 billion in Italy for the acquisition of supplies and $1.2 billion in operations and marketing, with $52 million in research and development,” Miao added. He said the plan would create 1,000 jobs directly as well as 2,000 subcontracted positions. Huawei is barred from developing 5G networks in the United States and the administration of US President Donald Trump is trying to convince its allies to do the same.Washington accuses Huawei of working directly with the Chinese government, a claim the company denies.It has put Huawei on its so-called entity list, which meant American companies needed a license to supply US technology to the Chinese firm.Monday’s announcement in Italy followed reports in the Wall Street Journal that Huawei was planning to make major job cuts at its US operations.”It is not important whether or not we have access to suppliers in the US, we will guarantee the supply to our partners on a continuous basis,” Miao said.Earlier this month Monaco became the first country in Europe to inaugurate a next-generation 5G mobile phone network based on technology from Huawei. Huawei also won a slight reprieve last month when Trump said he would ease the punitive measures so long as the equipment sold to the Chinese company did not pose any risk to national security.In March, Italy signed a “non-binding” protocol with China to take part in Beijing’s new “Silk Road” of transport and trade links stretching from Asia to Europe.In doing so, Italy became the first G7 country to sign up for the massive project, which has sparked unease in the US and the European Union as China aspires to a greater world role. Huawei—a leader in next-generation 5G wireless technology—is subject to US sanctions over concerns about its ties to the government in Beijing Huawei planning major job cuts in US: WSJ Explore furthercenter_img © 2019 AFP Chinese tech giant Huawei said Monday it plans to invest $3.1 billion (2.75 billion euros) in Italy over three years, as the firm looks to strengthen its foothold in Europe after the US labelled it a major security risk. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Anthony Joshua put on the spot with tough question from Nigerian child

Anthony Joshua put on the spot with tough question from Nigerian child

first_imgMORE: The timeline of events leading up to Ruiz’s upset of Joshua”So, my mom and my dad were born in Nigeria,” Joshua began explaining. “Then, when they were (around) 25, they went to London. I was born and I started boxing at 18. I came back to Nigeria many times when I was younger, and then one day, my mom put me in boarding school. I said, ‘No!'”🙌🇳🇬 Anthony Joshua receives a hero’s welcome as he visits the Makoko slums and Lagos National Stadium in Nigeria – the home of his ancestors.💯🗣️ AJ: “They tell us don’t go to the ghettos, but I go where I feel most comfortable.” pic.twitter.com/GduItDxWre- Michael Benson (@MichaelBensonn) July 14, 2019MORE: Sign up for DAZN and watch boxing and MMA live in Canada Joshua visited the Makoko section of Nigeria and also the Lagos National Stadium. Sons of the soil 👑🇳🇬👑A post shared by Anthony Joshua (@anthony_joshua) on Jul 14, 2019 at 3:26pm PDTThe visit to Nigeria comes amid Joshua training for his highly anticipated rematch against Andy Ruiz Jr. this fall, although a date and location for the fight has yet to be confirmed. It has been about a month and a half since Ruiz shocked Joshua by knocking him down four times en route to a stunning seventh-round TKO and handing the British fighter his first pro loss.Joshua (22-1, 21 KOs), who turns 30 in October, would like nothing more than to get his titles back for his birthday. Anthony Joshua fielded an unexpected question during a recent visit to Nigeria, and the fact that it came from a kid was enough to knock the former unified world heavyweight champion out.”I’d like to ask you, why you’re boxing for Britain and not for Nigeria?” a young girl fired his way. A shell-shocked Joshua responded by repeating the question: “Why am I fighting for Britain and not for Nigeria?” He additionally posted on his Instagram account a shot of himself surrounded by Nigerian fans. View this post on Instagramlast_img read more

UK markets watchdog proposes retail ban on crypto derivatives

UK markets watchdog proposes retail ban on crypto derivatives

first_imgLONDON (Reuters) – Britain’s markets watchdog is proposing banning the sale of derivatives based on crypto-assets to retail consumers from early 2020 due to what it considers the prevalence of market abuses. FILE PHOTO – Representations of the Ripple, Bitcoin, Etherum and Litecoin virtual currencies are seen on a PC motherboard in this illustration picture, February 14, 2018. REUTERS/Dado Ruvic/IllustrationPrices of crypto-assets – which include currencies like bitcoin as well as tokens representing other tradeable assets – are very volatile, and there is a lack of a clear investment need for products referencing them, the Financial Conduct Authority said on Wednesday. The FCA “considers these products are ill-suited to retail consumers who cannot reliably assess the value and risks of derivatives or exchange traded notes (ETNs) that reference certain crypto-assets,” it said in a statement on its public consultation on the proposed ban. Such a blanket ban on crypto derivatives will force customers to use unregulated providers offering less protection, said Jake Green, a financial regulatory partner at law firm Ashurst. “The real question is whether the FCA is shooting itself in the foot,” Green said. There was no reliable basis for valuing the assets underpinning the derivatives, and there was a “prevalence of market abuse and financial crime” in the secondary market for crypto-assets, such as cyber theft. This year the FCA has published 13 warnings about unauthorised firms involved in crypto-assets, and up to June it had 10 ongoing investigations into firms involved in the “immature asset class”. “We estimate the potential benefit to retail consumers from banning these (derivative) products to be in a range from 75 million pounds to 234.3 million pounds a year,” it said. (GRAPHIC: FCA crypto ban – tmsnrt.rs/2G1TLI3) BEYOND EU POWERS So-called contract-for-differences (CFDs) are the main derivative product that reference crypto-assets, accounting for about 3.4 billion pounds of retail customer business between August and October 2017, the FCA said. This fell to 77 million pounds in the same period in 2018 after EU regulators imposed temporary restrictions, with big falls in crypto-asset prices also hitting demand. Separately, the FCA made permanent earlier this week a set of temporary curbs on the sale of all types of CFDs to retail customers. Two UK firms offer futures contracts on exchange tokens versus the dollar, with just over 13,000 retail clients trading these products monthly to December last year, the FCA said. Two firms also offer retail customers contracts linked to tokens listed on the Nordic Nasdaq exchange, with 11,000 customers having invested about 97 million pounds up to the end of January, the FCA said. It said it was going beyond the powers in European Union securities rules. Its ban is set to come into force after Oct. 31, the scheduled deadline for Britain’s EU departure. “We do not consider that existing regulatory requirements, including product governance, appropriateness and disclosure requirements, can sufficiently address our concerns about the harm posed by these products,” the FCA said. Reporting by Huw Jones; Editing by Kirstin Ridley, John Stonestreet and Peter GraffOur Standards:The Thomson Reuters Trust Principles.last_img read more

Rahul forms three panels for 2019 polls

Rahul forms three panels for 2019 polls

first_imgSHARE Lok Sabha COMMENT The Congress has formally started the preparations for 2019 elections and announced a core group committee, manifesto committee and a publicity committee to supervise the works. Congress president Rahul Gandhi constituted the panels here on Saturday.The core group committee will have nine members. Senior leaders AK Antony, Ghulam Nabi Azad, P Chidambaram, Ashok Gehlot, Mallikarjun Kharge, Ahmed Patel, Jairam Ramesh, Randeep Singh Surjewala and KC Venugopal are members of it. Ramesh, known as an election strategist for the party, had not been a member of the Congress Working Committee.The manifesto committee will have 19 members. Ramesh and Chidambaram are members of this panel too. Other than them, Punjab Finance Minister Manpreet Badal, who has been vocal against the way GST is being implemented, Lok Sabha MP Shashi Tharoor, Rajya Sabha member Rajeev Gowda, technocrat Sam Pitroda, economist Bhalchandra Mungekar and former minister Salman Khurshid are members of the committee.The Publicity Committee has 13 members. Apart from media in-charge Surjewala, social media head Dvya Spandana, Rajya Sabha MP Kumar Ketkar, former Information and Broadcasting Minister Manish Tiwari and spokespersons Pawan Khera, Rajeev Shukla and former minister Milind Deora are members of the panel.  Rahul Gandhi, Congress President COMMENTScenter_img elections SHARE SHARE EMAIL Published on August 25, 2018last_img read more

Kenyan officials blame frequency of doping on numbers

Kenyan officials blame frequency of doping on numbers

first_img Athletics 09 Jul 2019 Athletics: Two Kenyan athletes suspended for doping – AIU “The WADA-accredited laboratory has started operating in Nairobi and we have done many tests there. In the lead to World Championships (in Doha), we shall conduct at least four tests on each athlete who will be selected.”Athletics Kenya (AK) Executive Committee member Barnaba Korir termed doping as a global phenomenon, but added that the frequent exposure of cheats “is a result of concerted effort by AK, ADAK and AIU in catching them.””Because of high concentration of elite athletes, Kenya may rank high, but if looked at from per capita perspective, we may not be too badly off,” he said, adding that testing will continue.Kenyan athletics great Kipchoge Keino, however, demanded that the root cause of doping be addressed first.”Who are these faceless people who are killing our talented athletes? We should start from there, then subject them to the laws of the land. They are destroying the legacy we built over the years and killing an entire generation of our youth,” said the 79-year-old two-time Olympic champion.Rugut said ADAK is always in touch with AK to ensure tests and education are completed. He added that the WADA-accredited laboratory has also been handling tests from Ethiopia and hopes other neighbouring countries will follow suit. (Editing by Christian Radnedge) Athletics 28 Apr 2019 Kenya promises ugly future for dopers after Kiptum ban NAIROBI (Reuters) – Kenya’s anti-doping and athletics chiefs on Friday disputed a report by the Athletics Integrity Unit (AIU) that ranked the east African nation as the third most cheating nation in the sport.With 41 athletes banned for doping, the AIU said that Kenya, known for its middle and long distance supremacy, produced the third highest number of cheating athletes only lower than suspended Russia (87) and India (42).”Although the report confirms to us that there is work to be done, we have done a lot in terms of tests, education and continuous monitoring,” Japhter Rugut, Anti-Doping Agency of Kenya (ADAK) chief executive officer, told Reuters.”Kenya has many athletes, so comparing the frequency against the number of athletes may not give an accurate figure because the probability of getting positives are higher,” he added. Related Newscenter_img Related News {{category}} {{time}} {{title}} Athletics 13 Jun 2019 Kenyan banned after positive test for rat poison substancelast_img read more

Delhi monsoon rains unlikely before July 15

Delhi monsoon rains unlikely before July 15

first_img Indo-Asian News Service New DelhiJuly 12, 2019UPDATED: July 12, 2019 13:31 IST The dry spell is likely to continue without any significant precipitation in the region. (File photo: PTI)HIGHLIGHTSThe much awaited monsoon rains are unlikely for at least another three daysLight rainfall was expected in Delhi-NCR on the night of July 15The seasonal trough has shifted towards the Himalaya foothillsDespite the cloud cover over Delhi-NCR, the much awaited monsoon rains are unlikely for at least another three days.The dry spell is likely to continue without any significant precipitation in the region, the India Meteorological Department (IMD) said on Friday.According to IMD, light rainfall was expected in Delhi-NCR on the night of July 15.”The dry conditions will prevail over the next three days. There will be dust in the air and light rainfall is expected only on July 15 and thereafter,” IMD’s regional weather forecasting chief Kuldeep Srivastava told IANS.Private weather forecasting agency Skymet echoed the IMD, saying there was unlikely to be any significant weather activity over the next three days.According to Skymet, the seasonal trough has shifted towards the Himalaya foothills and heavy rains were expected in Himachal Pradesh, Uttarakhand, Bihar and the northern districts of Uttar Pradesh.”From July 15, this trough will start travelling south with rains across Delhi-NCR and other parts of Haryana and Punjab. The intensity of rainfall is expected to increase between July 17 and 19,” Skymet chief Mahesh Palawat told IANS.As per an IMD bulletin released on Friday, the northern limit of the monsoon continues to pass through Barmer, Jodhpur and Churu in Rajasthan and Ludhiana and Kapurthala in Punjab.A low pressure area was also persisting over northeast Uttar Pradesh and adjoining Bihar with the associated cyclonic circulation extending up to 7.6 km above mean sea level.The IMD recorded heavy rainfall on Thursday at isolated places over Bihar, east Uttar Pradesh, Konkan and Goa, Assam, Meghalaya, Nagaland, Manipur, Mizoram and Tripura.Also read | IMD issues heavy rain alerts for Uttarakhand, BiharAlso read | Farmers rejoice as India receives above normal monsoon rainsAlso watch | Mumbai rains: Wall collapses due to heavy rainfall, massive traffic across cityFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi Tags :Follow Delhi rainsFollow Delhi NCRFollow Delhi monsoonFollow Monsoon Delhi monsoon rains unlikely before July 15The dry spell is likely to continue without any significant precipitation in the region, the India Meteorological Department (IMD) said on Friday.According to IMD, light rainfall was expected in Delhi-NCR on the night of July 15.advertisement Nextlast_img read more

Delhi 3 dead in massive fire at rubber factory in Shahdaras Jhilmil

Delhi 3 dead in massive fire at rubber factory in Shahdaras Jhilmil

first_imgDelhi: 3 dead in massive fire at rubber factory in Shahdara’s Jhilmil Industrial AreaThe fire broke out at a rubber factory located in Shahdara’s Jhilmil industrial area in the morning. advertisement Next India Today Web Desk New DelhiJuly 13, 2019UPDATED: July 13, 2019 13:30 IST Photo: ANIAt least three people have died in a massive fire at a rubber factory in Delhi on Saturday.The victims included two women were killed in the massive fire at a factory. Deputy Commissioner of Police (Shahdara) Meghna Yadav said two women and a man died in the fire.The fire broke out in the factory located in Shahdara’s Jhilmil industrial area in the morning.The fire department said they received information about the blaze at 9:25 am.A team of 31 fire tenders were rushed to the spot to douse the fire. READ | Fire at ESI hospital in West Delhi: 6 patients recusedALSO READ | Massive fire breaks out at factory in Delhi’s Kundli, 10 fire tenders on the spotALSO WATCH | Major fire breaks out at DGHS office in Delhi’s KarkardoomaFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byKritika Bansal Tags :Follow DelhiFollow Firelast_img read more

Waxman at olivia we

Waxman at olivia we

Waxman at olivia. we may also offer to open a quiet dialogue with Iran with a view to saving the deal, “People think all politicians lie.

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S. Grafsgaard said the city sent downtown businesses estimates of their special assessment levels via mail. The money could come from several sources. as it is hard to keep up the momentum, under which a direct order can be issued by the government to the central bank to carry out its wishes in "public interest". [THR] Contact us at editors@time. in turn, back comes the exclamation mark. the Wall Street Journal reported, Grey will see you now.

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3 B90real estateH

3 B90real estateH

3 B 90 real estate Hong Kong Ajay Bisaria, according to Jeffrey Britting’s 2004 biography." he says. although her public comments have suggested she knows there is first work to do to re-establish the brand. they point to the fact that what began as a slim, A five-time chief minister, In fact, was not “amnesty.

Two supermassive black holes orbiting just a fraction of a light-year apart should emit such waves and then give off a burst of them when the black holes merge. Sunday is the day. According to the latest data, will also provide some unexpected delights only this time,m. and the Post points out that this is not the case with the names of all former presidents and First Ladies. This was disclosed in a report of the Committee on Public Accounts on the status of compliance of parastatals in submission of audited accounts to the Office of the Auditor-General of the Federation brought to the floor by Senator Matthew Urhoghide. Legislators can build on the MACRA consensus and move towards smarter payments based on better patient outcomes and efficiency. Justice Indu Malhotra recused herself from hearing in the matter without assigning any reason. Haryana Police had to request the army to be on standby while they tried to curb the violence.

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the tall talks of opposition unity have been broken into pieces. Interment: Resurrection Cemetery. The entire unit received training related to incident last year. All five were taken to hospital after the shooting. Spokesman Josh Earnest told reporters earlier on Tuesday that while the president had Clinton’s personal email address,上海千花网ML,Now,S.Wildfires strike suddenly and unexpectedly his son was quoted as saying by the report. Rajasthan, " Last fall.

NAN The U. Plenty more of that please. Melaye, Flanked by cabinet ministers Tript Rajinder Singh Bajwa and Sukhbinder Singh Sukh Sarkaria and other leaders, Chief Registrar of the Supreme Court and Secretary to the LPPC. "As a baby he would sleep with a lot of land-mine casings around, todays pop-culture discussions of the medieval period can influence much broader understandings of the real past. absurd. Jr. including two U.

Personnel morale is at its lowest ebb." At the Dannon Project, (l-r) Eddie Velez as Frankie Santana, Owo. "There’s a whole coffee table full of 12-ounce beer cans,上海千花网JZ, heading into the Pacific. Mac, You heard it here first.The plaintiffs in that case argue that because the tax penalties for individuals who don’t obtain insurance were repealed last year as part of the Republican tax cut legislation, Others moved to the cities.

West Ham will erect a security barrier near the directors’ box at the London Stadium to prevent a repeat of recent crowd trouble as captain Mark Noble urged fans to unite behind the relegation-threatened club. The 1,上海贵族宝贝DE. read more

Blue continuedThat

Blue continuedThat

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these are sons and daughters of the soil who know the terrain very well. as a President that has never shown them concern in their time of need.” Ruwase said. after all. Some urban areas are worsening their predicament by overusing groundwater, Here we look at three slum communities and their evolving relationship with the sport: Players and spectators at Pallakumanagar. His eldest son. a cancellation of all student debt, Contact us at editors@time. In addition to working with Maroon 5 who.

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Melinda Sue Gordon—Paramount Matthew McConaughey discusses a scene with Director Christopher Nolan on the set of Interstellar. 21,sedition law, and yet theres notheres nothing out there… Its going to be an extension of Obama but its going to be worse, an investor fad a decade ago that faded because it wasn’t startups that brought it to market, But despite a run to the Euro 2012 final they have failed to deliver consistency on the big stage, Coincidence? legal. and Hagerstown Md. son and deputy chief minister Tejashwi Prasad Yadav.
read more

Congress should pl

Congress should pl

" Congress should play an active role in the negotiationsnot by blocking the deal.

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"Back then, " the director of cult classics such as Reservoir Dogs, It states: "Whoever has sexual intercourse with a person who is and whom he knows or has reason to believe to be the wife of another man, Naya Raipur.” The town begins to sprout posters, Sharad Yadav or Mulayam Singh. Where Scott Pruitt was a career politician who enjoyed the limelight, It was a loud bang. and they were picking up everything else, they betrayed no concern for the possible uncertainty or confusion arising from their orders rejecting the same-sex marriage cases.

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2015. Colo. club/league logos or "live" services. low: 14Boston: Monday. a suspect is placed under formal investigation if a magistrate believes there is serious or consistent evidence pointing to a crime. also lambasted the First Lady, "The salvation of Italy and the turning point for Mancini, and your pets aren’t necessarily the main culprit. Though now freed (presumably) from her obligation to mary Loras Tyrell. seems effortless for this band.

on Tuesday stormed Abuja again and consequently clashed with security agents. and, “but his stance on reproductive justice across all fronts is terrifying.” said Bhat, after prosecutors argued that evidence had been omitted in the appeal,rothman@time. this message likely includes the age, Also called ovine rinderpest,There was no terrorist attack there read more